Earl J Crain Selected Research

Carotid Artery Thrombosis

4/2016	The P2Y1 receptor antagonist MRS2500 prevents carotid artery thrombosis in cynomolgus monkeys.
1/2009	Clopidogrel versus prasugrel in rabbits. Effects on thrombosis, haemostasis, platelet function and response variability.
8/2007	Razaxaban, a direct factor Xa inhibitor, in combination with aspirin and/or clopidogrel improves low-dose antithrombotic activity without enhancing bleeding liability in rabbits.
5/2007	Platelet aggregometry and receptor binding to predict the magnitude of antithrombotic and bleeding time effects of clopidogrel in rabbits.
12/2002	Nonpeptide factor Xa inhibitors III: effects of DPC423, an orally-active pyrazole antithrombotic agent, on arterial thrombosis in rabbits.

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Earl J Crain Research Topics

Disease

11	Thrombosis (Thrombus) 01/2022 - 12/2002
5	Hemorrhage 01/2020 - 12/2002
5	Carotid Artery Thrombosis 04/2016 - 12/2002
2	Weight Loss (Weight Reduction) 01/2009 - 05/2007

Drug/Important Bio-Agent (IBA)

3	Factor XIa (Coagulation Factor XIa)IBA 01/2022 - 01/2020
3	Fibrinolytic Agents (Antithrombotic Agents)IBA 01/2020 - 12/2002
3	AnticoagulantsIBA 01/2020 - 12/2002
3	Clopidogrel (Plavix)FDA Link 01/2009 - 05/2007
2	EnzymesIBA 01/2022 - 01/2020
2	Factor Xa InhibitorsIBA 08/2007 - 12/2002
1	milvexianIBA 01/2022
1	pyridineIBA 01/2020
1	cangrelorIBA 04/2016
1	Abciximab (ReoPro)FDA Link 04/2016
1	Purinergic P2Y1 ReceptorsIBA 04/2016
1	2- iodo- N(6)- methyl- (N)- methanocarba- 2'- deoxyadenosine- 3',5'- bisphosphateIBA 04/2016
1	compound 21IBA 01/2016
1	BMS-262084IBA 08/2011
1	apixabanIBA 01/2010
1	Adenosine Diphosphate (ADP)IBA 01/2009
1	ThienopyridinesIBA 01/2009
1	Prasugrel Hydrochloride FDA Link 01/2009
1	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 08/2007
1	razaxabanIBA 08/2007
1	Thrombin FDA Link 12/2002
1	Enoxaparin (Lovenox)FDA LinkGeneric 12/2002
1	1- (3- (aminomethyl)phenyl)- N- (3- fluoro- 2'- (methylsulfonyl)(1,1'- biphenyl)- 4- yl)- 3- (trifluoromethyl)- 1H- pyrazole- 5- carboxamideIBA 12/2002
1	Low-Molecular-Weight Heparin (Heparin, Low Molecular Weight)IBA 12/2002
1	argatroban (MPQA)FDA Link 12/2002
1	pyrazoleIBA 12/2002

Therapy/Procedure

3	Therapeutics 01/2020 - 08/2007
1	Intravenous Administration 12/2017